Dr. Maréchal and his team are investigating RFWD3, a protein involved in DNA repair, to understand how it helps cancer cells survive chemotherapy. They believe RFWD3 influences DNA gap repair, which is crucial for cell survival under stress. By studying its function in cancer cells, they aim to uncover new ways to overcome drug resistance. Targeting RFWD3 or related repair pathways could lead to improved treatments, making chemotherapy more effective for patients with drug-resistant ovarian cancer.